To develop our ACP library we varied acid strength, net charge, and charge distribution along the sequence (Figure S1, Supporting Information) of a non‐selective pore‐forming template sequence.[40] Remarkably, our lead ACP (EEK) is neutral (taking the positive N‐terminus into account) and several active ACPs in the library (e.g., EEE) are anionic, underscoring the unpredictability and complexity of tuning cancer selectivity. This evidence concerns the gene NDUFAB1 and cancer.