BCL2L1 and neoplasm: Intra‐vesicular cleavage of Bcl‐xL by caspase‐3 required for EV uptake by malignant blood cells. EV‐loaded caspase‐8 and membrane receptors suggest caspase‐3 activation may occur within EVs, potentially via EV membrane stimulus. Caspase‐3 inhibition resulted in reduced cell proliferation in recipient tumour cells.