TCGA classification includes four groups: EBV-associated tumors (2–5%), tumors with MSI (about 10%), chromosomal instability (CIN) (about 40%) of patients and comprise the histological intestinal group, and the genomic stable (GS) group of tumors which harbors the diffuse histological type and is associated with CDH1 mutations (about 40%). This evidence concerns the gene CDH1 and cervical squamous intraepithelial neoplasia.