DLG2 also interacted with 4 proteins (NOS1, ERBB4, DLGAP2, NRXN3) which were among the top 1000 leading AD-associated single rare variants and regions [19], and 4 proteins (GRIN1, GRIN2A, GRIN2B, GAPDH) associated with AD in the KEGG Alzheimer’s pathway. Here, NOS1 is linked to Alzheimer disease.