Compared to luminal-like subtype disease, the HER2 and TN subtypes of LMBC presented a higher grade (P < 0.0001), a larger tumor size (P < 0.0001), a higher rate of node involvement (P < 0.0001), and a higher incidence of brain metastasis (P < 0.0001). This evidence concerns the gene ERBB2 and neoplasm.