The multiple logistic regression analysis adjusted for age, sex, BMI, diabetes, hypertension, smoking, consumers of alcohol, FPG, HbA1c, ApoB, ApoA1, TC, TG, HDL-C, hs-CRP, and HCY, the level of Lp(a) remained to be independently associated with the presence and severity of CHD (CHD group vs. control group: OR = 1.793, 95% CI: 1.053–2.882, p = 0.043; multiple-vessel disease group vs. single-vessel disease group: OR = 1.941, 95% CI: 1.113–3.242, p = 0.027; high GS group vs. low GS group: OR = 2.641, 95% CI: 1.102–7.436, p = 0.040). This evidence concerns the gene LPA and diabetes mellitus.