MGMT and glioblastoma: et al., studied the association of O6-methylguanine-DNA methyltransferase (MGMT) gene rs16906252 polymorphism with DNA methylation and reported that the individuals with MGMT rs16906252 T-allele has 5.5 folds and 2.64 folds highly methylated than C-allele individuals in colorectal cancer and glioblastoma patients respectively67,68.