Accumulating evidences have shown that the genetic variants of the APOE, LDLR, SH2B3, TIMP1, MMP9 genes were found to have an impact on risk of the diseases like diabetes, coronary artery disease, acute lymphoblastic leukemia, cancer, lung cancer, etc21,36,45,52,81–87. The gene discussed is LDLR; the disease is diabetes mellitus.