Notably, expression of ULK1 R170K mutation attenuated low-oxygen-induced phosphorylation of ULK1 T180, Atg13 S355 and Beclin 1 S15, and accordingly further curbed tumor growth (Fig. 4g) with repressed cell proliferation (Fig. 4h) and increased cell death (Supplementary Fig. 6i). This evidence concerns the gene BECN1 and neoplasm.