Because FOXO1 contributes to endothelial dysfunction and has been shown to directly bind to the ICAM-1 promoter and activate ICAM-1 transcription [37, 38], it is plausible to speculate that SIRT6 might modulate oxLDL-induced ICAM-1 expression by targeting FOXO1. Here, FOXO1 is linked to endothelial dysfunction.