Since Zeb1 regulates expression of the glycolytic rate-determining enzymes HK2, PFKP and PKM2 that modulate cancer cell proliferation and/or apoptosis [4–7], the function of Zeb1 in aerobic glycolysis at least partly explains the phenotypes induced by Zeb1 depletion in breast cancer cells. This evidence concerns the gene HK2 and breast cancer.