There are various epidermal growth factor-like domain protein 6 (MEGF6) in CRC, which induce EMT via transforming growth factor β (TGFβ)/SMAD signaling pathway to promote the transfer of CRC.192 Through the analysis of expression profile microarray data, it is concluded that apolipoprotein E (ApoE) expression in normal mucosal tissues, primary CRC and CRLM increased sequentially.193 The overexpression of ApoE is related to the progression of CRC, especially for stage II and simultaneous liver metastases, resulting in a poor prognosis for CRC patients. The gene discussed is APOE; the disease is colorectal carcinoma.