The Trop-2 expression is another necessary for tumorigenesis and invasiveness of CRC cells.189 Interestingly, ZFP57, an embryonic stem cell-specific transcription factor has been shown to promote liver metastasis of CRC.190 Tang et al.191 found phosphoprotein enriched in astrocytes-15 kDa (PEA15) was highly expressed in CRLM patients compared to non-metastatic. The gene discussed is ZFP57; the disease is colorectal carcinoma.