The CXCL5/CXCR2 biological axis promoted tumor angiogenesis by activating the AKT/NF-κB/FOXD1/VEGF-A pathway.63 Moreover, Zhao et al.64 found the elevated expression of CXCL5 in CRC induced cell migration by the ERK/Elk-1/Snail signaling pathway and promoted cell invasion through the AKT/GSK3β/β-catenin/MMP7 signaling pathway. This evidence concerns the gene CXCR2 and neoplasm.