The tumor-suppressive miR-15a and miR-16-1, which targeted AP4 3′-UTR, and inhibited CRC cell migration and invasion.261,262 Overexpression of miRNA let-7 promoted EMT via targeting HMGA2263, while Lin28 could inhibit let-7 in conjunction with OCT4, SOX2, and KLF4.264 MiR-10a suppressed CRC metastasis by regulating the EMT via targeting matrix metalloproteinase 14 and actin gamma 1 (ACTG1).265 Unlike miR-10a, upregulated miR-10b in metastatic CRC tissues and cell lines inhibited E-cadherin expression and enhanced cyclin D1, which were partly abrogated after targeting KLF4.266. This evidence concerns the gene KLF4 and neoplasm.