Exosomal miRNAs miR-25-3p, miR-130b-3p, miR-425-5p secreted by CRC cells via activation of the CXCL12/CXCR4 axis, could be transferred to macrophages which can then target PTEN and shift the macrophage towards M2 phenotype.106 Additionally, mutant p53 CRC could reprogram macrophages into M2 macrophages by transferring exosomal miR-1246.116. This evidence concerns the gene TP53 and colorectal carcinoma.