JAK2 and colorectal carcinoma: In addition, SOX13 is induced by HGF through JAK2/STAT3 signaling and then upregulated SOX13 transactivates the expression of c-MET by directly binding to its promoters, which contributes to c-MET overexpression in CRC.133 This feedback loop induces SOX13-mediated CRC migration, invasion, and metastasis.