ANGPTL1, a tumor suppressor, was decreased in CRC tissue.85 Exosomal ANGPTL1 decrease MMP9 production in Kupffer cell by suppressing the JAK2-STAT3 signaling pathway.86 Tumor cells can transfer EMT inducers, such as IL-6, Akt and TNF-α, through exosomes to induce EMT in neighboring tumor cells.87 Here, STAT3 is linked to neoplasm.