In detached CRC cells, under the action of carnitine palmitoyl transferase 1, FAO was greatly activated, thus increasing the ability of cells to metastasize.324 CRC cells implanted in the liver promoted the metabolism of fructose by upregulating enzyme aldolase B (ALDOB), which provided energy for cell growth in liver metastases.325 This particular metabolic pathway change was found only in liver metastases and not in other sites of metastasis or primary tumors. This evidence concerns the gene ALDOB and colorectal carcinoma.