Moreover, exosomal miRNAs are secreted by cancer-associated fibroblasts (CAFs), then they are transferred to CRC cells.98 Mechanistically, miR-92a-3p inhibits mitochondrial apoptosis by activating the Wnt/β-catenin pathway and inhibiting FBXW7 and MOAP1, thereby enhancing stemness, EMT, metastasis and 5-FU/L-OHP resistance of CRC cells.98 Reducing exosomal miR-92a-3p may contribute to the prediction and treatment of CRLM. This evidence concerns the gene MOAP1 and colorectal carcinoma.