The Notch pathway plays a positive role in CRLM and inhibition of Notch signaling interferes with CRLM.122 The human Notch system includes four Notch receptors (Notch1-4) and five Notch ligands (Jagged1-2, DLL1, DLL3, DLL4).152 Activation of the Notch pathway is related to the poor prognosis of CRC. This evidence concerns the gene JAG1 and colorectal carcinoma.