They also found that miR-497 targeted the expression of vascular endothelial growth factor-A (VEGF-A).281 Notably, miR-497 exerted its oncogenic function by targeting fos-related antigen-1 (Fra-1).282 Recently, AGAP2-AS1 regulated fibroblast growth factor receptor 1 (FGFR1) expression by sponging miR-497 in the migration and invasion of CRC cells.283. This evidence concerns the gene FOSL1 and colorectal carcinoma.