Moreover, Ferritin Light Chain (FTL) as an oncogene leads to CRC cell resistance against 5-FU treatment and promoted CRC metastasis by competing with lncRNA Linc00467 for miR-133b binding site.202 The expression of defensin β 4 A (DEFB4A) was significantly upregulated and experimentally proved that DEFB4A gene knockdown proved that DEF4BA promoted cell migration.203 Sialyltransferase ST6GAL1 can increase the stability of ICAM-1 through sialylation, thereby inhibiting the transfer characteristics of CRC.204. This evidence concerns the gene DEFB4A and colorectal carcinoma.