TIMP3 and colorectal carcinoma: circRNAs also play an inhibition role of CRLM, for example, circRNA Hsa_circ_0009361 acted as an inhibitor for miR-582 and suppressed the CRC cell metastasis.245 Similarly, circRNA-FNDC3B negatively and directly regulated miR‐937‐5p to promote the expression level of the tumor‐suppressor TIMP3, thereby blocking the metastasis, invasion and angiogenesis of CRC.246 In addition, circITGA7 inhibited the Ras signaling pathway and promoted the transcription of ITGA7, thereby suppressed the proliferation and metastasis of CRC cells.247