When cancer cells form a glandular structure again in the center of metastatic nodules, the expression level of S100A6 decreases.195,196 Knockdown of S100A4 restricts metastasis formation in a xenografted mouse model of CRC.197 Moreover, S100A8, another member of the S100 family is correlated with TIMP-1-induced PMN in liver.198. The gene discussed is S100A4; the disease is cancer.