Then circ-133 adsorbed miR-133a to target GEF-H1/RhoA, as a result of reducing the distribution of E-cadherin on the membrane.112 Guo et al.96 reported fusobacterium infection may stimulate CRC cells to generate CXCL16/RhoA/IL-8 exosomes that are delivered to uninfected cells to promote prometastatic behaviors. This evidence concerns the gene CXCL8 and colorectal carcinoma.