SOX2 and neoplasm: It has been reported that miR-200 family (miR-200a, miR-200b, miR-200c, miR-141, and miR-429) are recognized as regulators of the epithelial phenotype through repression of ZEB1 and ZEB2 mRNA translation250–252 The miR-200c levels in primary CRC without liver metastasis is lower than the metastasis with primary tumor tissues, which highlight a crucial role for miR-200c in CRC metastasis.251 The overexpression of miR-429 could play an oncogenic role in the cellular processes of CRC by targeting SOX2.253