Methyltransferase like 3 behaves as the ‘writer’ of m6A promoted m6A-methylation of oncogenic lncRNA XIST to inhibit CRC proliferation and invasion.212 LncRNA LINC01578 activity was enhanced when nuclear factor kappa B (NF-κB) and Yin Yang 1 (YY1) were directly bound to the LINC01578 promoter.213 Meanwhile, upregulated LINC01578 interacted with and recruited EZH2 to NFKBIB promoter and further repressed NFKBIB expression, thereby activating NF-κB signaling. This evidence concerns the gene NFKBIB and colorectal carcinoma.