IL6 and colorectal carcinoma: Similarly, CRC-derived exosomes packed with miR-21-5p created a liver pro-inflammatory phenotype and liver metastasis of CRC via the miR-21-Toll like receptor 7-IL-6 axis.90 Metastasis-associated miR-106b-3p from serum exosomes targeted deleted in liver cancer-1.91 Elisabetta et al.92 reported that exosomal miR-210 can perhaps be reckoned as an EMT signal promoter which maintain the local cancer-growth milieu and influence the adhesion and migration of CRC cells.