PTEN and colorectal carcinoma: Akt2 is one of the three subtypes in the Akt family, as it promotes cell movement/invasion.184,185 Akt2 is highly expressed in stage IV CRCs and liver metastases, meanwhile, loss of PTEN and overexpression of Akt2 synergistically promote metastasis.186 The inducible loss of Akt2 in CRC cells strongly upregulates metastasis Suppressor 1 (MTSS1) at the messenger RNA and protein levels.187 MTSS1 is a new gene regulated by Akt2, where the inhibition of MTSS1 is a key step for Akt2 to promote metastasis in CRC cells.