CRC-derived exosomes contain various biomolecules such as protein (PAD4, FasL, TGFβ, angiopoietin-like protein 1 (ANGPTL1), AKt, tumor necrosis factor-α (TNF-α), β-catenin), RNA (miR-246, miR-21, miR-25-3p, miR-375-3p, miR-92b-3p, miR-27a-3p, miR-17, MALAT1). The gene discussed is TNF; the disease is colorectal carcinoma.