HGF and colorectal carcinoma: High expression of circulating HGF and aberrant activity of cMet were detected in patients with CRC.126 Inhibition of HGF/C-MET signaling pathway could decrease the proliferation and invasion of CRLM.127 By assessing the patient tissue samples, Yao et al.128 reported higher levels of c-Met expression (mRNA and protein) in CRLM than primary CRC by assessing the patient tissue samples.