Zeng et al.89 found that exosomal miR-25-3p secreted by CRC cells was transferred to vascular endothelial cells and promoted CRC metastasis by targeting Kruppel-like factor 2 and Krüppel-like factor 4 (KLF4) to increase vascular permeability and promote angiogenesis in animal models. This evidence concerns the gene KLF4 and colorectal carcinoma.