AKT1 and colorectal carcinoma: NSUN2 was more likely to enter the cytoplasm, then in the cytoplasm increased the stability of HMGA2 mRNA to induce CRC metastasis progression.236 Equally noteworthy, circRNA circ_0124554 inhibited the ubiquitination of AKT to promote the early metastasis particularly for the lymph node-negative CRC patients with synchronous liver metastasis.237