CDK4 and colorectal carcinoma: A new member of the F-box protein family, FBX8, containing F-box and Sec 7 domain, can ubiquitinate and degrade HIF-1α such as CDK4 and C-Myc, downregulating their ability for promotion of angiogenesis, cycle progression and cell proliferation, respectively, thus regulating the CRC liver metastasis dormancy.199 Moreover, Thrombospondin-1 (THBS1) depletion inhibited migration and invasion of CRC cells through attenuating EMT.200 Upregulated THBS1 may be significantly correlated with CRLM, which requires further study.