There is also a noticeable interaction between CRC cells and TAMs via exosomes.113 Exosomes secreted by M2 macrophages promoted CRC migration by exosomal transfer of miR-21-5p and miR-155-5p.114 Mechanistically, these miRNAs mentioned above targeted the core component of the Switch/sucrose non-fermentable complex BRG1. This evidence concerns the gene SMARCA4 and colorectal carcinoma.