The NF-κB/p65 signaling pathway has a critical role in the mediation of GNA13 in CRC which was indicated by a decrease in GNA13-induced migration, invasion, and in addition, CXCL chemokine level increases after the inhibition of NF-κB/p65 signaling pathway with an inhibitor.70 The novel quinazoline derivative MJ-56 interfered with the NF-κB signaling via impairing PI3K/AKT activation and subsequently reduced the NF-κB-mediated transcription of MMPs.208. This evidence concerns the gene NFKB1 and colorectal carcinoma.