MALAT1 and colorectal carcinoma: Furthermore, the exosome-derived lncRNAs could play essential roles in tumorigenesis by regulating the TME.109 Exosomal lncRNAs BCAR4 could be potential candidates to detect CRC.110 Exosomal MALAT1 regulated fucosyltransferase 4 (FUT4) expression by sponging miR-26a/26b to promote CRC progress.111 CRC cells secreted exosome cirC-133 into relatively normoxic CRC cells under hypoxic conditions.