Research and development of L1CAM inhibitory molecules-as a treatment of diffuse residual disease and metastatic disease is of great significance.183 The scattered Lgr5 low and L1CAM high cells in the primary tumor can trigger the distant metastasis of CRC, but will dynamically emerge from the Lgr5 high primary tumor when the epithelial integrity is lost during the self-destructive tumor infiltration process, which is a distant metastatic organ necessary for the survival and re-growth of diffuse cancer cells. Here, LGR5 is linked to metastatic neoplasm.