NOTCH1 and colorectal carcinoma: Ectopic expression of tRNA-derived fragments (tRF)/miR-1280 reduced cell proliferation and metastasis by directly inhibiting the Notch signaling via targeting JAG2, leading to the decreased activity of Notch pathway components and Notch signaling.165 Moreover, the intensity of Notch1 expression was related to depth of invasion, tumor node metastasis (TNM) staging and lymph node metastasis of CRC.166 Inhibition of tumor-derived Tumor-Derived Laminin α5 (LAMA5) activated the Notch pathway in tumor endothelial cells, thereby reducing branching angiogenesis.167