In the extracellular space, creatine kinase brain (CKB) used ATP-catalyzed phosphorylation of the metabolite creatine to form phosphocreatine, which can produce large amounts of ATP into CRC cells as an energy reserve to maintain the energy requirements of CRC cells during anoxia during metastasis.323 CKB promoted the development of liver metastasis, and targeted inhibition of its activity was also the direction of future treatment of CRLM. The gene discussed is CKB; the disease is colorectal carcinoma.