MTOR and colorectal carcinoma: MiR-133a, as a tumor suppressor, inhibited cell proliferation, invasion, and migration by targeting oncogenic EIF4A1.284 MiR-99b-5p was differently expressed in primary CRC and liver metastasis and functioned as a tumor-suppressive miRNA to affect cell migration by targeting mTOR in metastatic CRC.285 In an orthotopic mouse model of CRC, Ding et al.286 found that APOBEC3G enhanced CRC cell migration and invasion via inhibition of miR-29-mediated suppression of MMP2.