Among the causal candidate vascular genes identified by MR, ARRB1 (OR: 0.84, 95% CI 0.78–0.91, Pcausal = 9.45 × 10–6) and MFGE8 (OR: 1.13, 95%CI: 1.09–1.17, Pcausal = 2.08 × 10–12) were the genes with the highest effect size on the risk of CAD. The gene discussed is MFGE8; the disease is coronary artery disorder.