Among those genes, several novel causal candidates, which have not been investigated in the context of atherosclerosis, were identified and include EXOSC5, B3GNT8, ARRB1, PIF1, UTP11, AGPAT4 and MAP3K11. For instance, MR data indicate that the vascular expression of AGPAT4 is negatively associated with CAD-risk. The gene discussed is PIF1; the disease is coronary artery disorder.