Considering the directional effects in MR, 5 vascular genes are potential targets for drug inhibition (CTSK, MAP3K11, KCNH2, ATP1B1, CAMK1D). For instance, the vascular expression of CAMK1D which encodes for a calcium calmodulin dependent protein kinase, is positively associated with the risk of CAD in MR (OR: 1.11, 95% CI 1.07–1.16, Pcausal = 5.12 × 10–8) (Fig. 4B). The gene discussed is CTSK; the disease is coronary artery disorder.