Among these genes, 33 did not show heterogeneity (Cochran’s Q test > 0.05) and were considered as causally associated with CAD (MRAS, HHIPL1, CDH13, JCAD, MFGE8, BMP1, FGD6, CTSK, MAP3K11, TMEM133, CAMK1D, DMPK, ZEB2, EIF2B2, HSD17B12, CDC25A, ARRB1, SFMBT1, TRIP4, KCNH2, NME7, ATP1B1, MRPL35, CCDC181, AGPAT4, RNF123, ANKDD1A, BEND6, CTSH, NPHP3, PIF1, ALKBH5, MEAF6) (Fig. 3) (Additional file 9: Table S9). Here, CCDC181 is linked to coronary artery disorder.