ARRB1 and coronary artery disorder: Predicted CAD causally associated vascular genes in MR and acting as hub gene (high degree in PPI network) include among others ARRB1 (OR: 0.84, 95%CI: 0.78–0.91, Pcausal = 9.46 × 10–6), CDC25A (OR: 0.96, 95% CI 0.95–0.98, Pcausal = 5.33 × 10–6), KCNH2 (OR: 1.03, 95% CI 1.01–1.04, Pcausal = 7.14 × 10–5) and MAP3K11 (OR: 1.07, 95%CI: 1.05–1.10, Pcausal = 8.46 × 10–9).