CTSK and coronary artery disorder: In GTEx, gene variant A-rs12042263 (strongest IV in MR for the expression) (EUR freq = 0.91) is associated with a lower vascular expression of CTSK (PeQTL = 1.69 × 10–10) and a decreased risk for CAD (OR: 0.96, 95% CI 0.95–0.98, PGWAS = 1.18 × 10–3).