Allele G-rs9349379 (EUR freq = 0.40) increases the risk of CAD (OR: 1.11, 95% CI 1.10–1.12, PGWAS = 2.71 × 10–76) and is associated with a decreased expression of PHACTR1 in the aorta (Fig. 2B). This evidence concerns the gene PHACTR1 and coronary artery disorder.