Among the 33 vascular genes associated with CAD in IVW MR, we found that 29 genes (MFGE8, CAMK1D, CTSK, JCAD, CDH13, EIF2B2, MAP3K11, FGD6, RNF123, ATP1B1, SFMBT1, MRPL35, MRAS, KCNH2, NPHP3, ANKDD1A, BEND6, CTSH, NME7, CCDC181, HSD17B12, TRIP4, CDC25A, TMEM133, DMPK, ZEB2, ARRB1, BMP1, HHIPL1) were also significant in weighted median MR analysis (Additional file 12: Table S12). Here, MAP3K11 is linked to coronary artery disorder.