Among these genes, 33 did not show heterogeneity (Cochran’s Q test > 0.05) and were considered as causally associated with CAD (MRAS, HHIPL1, CDH13, JCAD, MFGE8, BMP1, FGD6, CTSK, MAP3K11, TMEM133, CAMK1D, DMPK, ZEB2, EIF2B2, HSD17B12, CDC25A, ARRB1, SFMBT1, TRIP4, KCNH2, NME7, ATP1B1, MRPL35, CCDC181, AGPAT4, RNF123, ANKDD1A, BEND6, CTSH, NPHP3, PIF1, ALKBH5, MEAF6) (Fig. 3) (Additional file 9: Table S9). This evidence concerns the gene PIF1 and coronary artery disorder.