DOX upregulates miR-200c, which downregulates ZEB1 (zinc finger e-box binding homeobox 1), endothelial nitric oxide synthase, Sirtuin1 (SIRT1), and Forkhead boxO1, leading to epithelial dysfunction and DOX-related cardiotoxicities such as cardiomyopathy, cardiac apoptosis, and CHF [312, 313]. Here, ZEB1 is linked to congestive heart failure.