As a natural flavonoid, fisetin was confirmed to prevent high fat diet-induced diabetic nephropathy through the suppression of insulin resistance and the inflammation mediated by RIP3 [55], and reduce the inflammation of kidneys and apoptoses by inhibiting the Src-mediated NF-κB p65 and MAPK pathways to guard against the LPS-induced septic AKI mice [56]. The gene discussed is INS; the disease is diabetic kidney disease.