On the other hand, NETosis in systemic lupus erythematosus (SLE), inhibition of TGF-β1 signaling, IL-1 signaling, transcription androgen receptor nuclear signaling, and inhibition of RUNX3 signaling were the main enriched pathways in Th2-enriched CD4+ T cells from peripheral blood in AR patients (Fig. 2B). The gene discussed is IL1B; the disease is systemic lupus erythematosus.