IGF1 and graft versus host disease: The expression level of pro-mitotic fibroblast growth factor receptor 1 (FGFR1) was lower in MSCs which could not prevent GVHD, and the expression levels of peroxisome proliferator-activated receptor gamma (PPARG) and insulin like growth factor 1 (IGF1), biomarkers associated with MSC differentiation and senescence, were significantly higher, indicating that senescent MSCs are worse at preventing aGVHD [43].