INS and Hypoglycemia: The initial total daily dose of insulin recommended to avoid both hypoglycemia and hyperglycemia is 0.4–0.6 IU/kg of body weight [52], but may be lower, at 0.2 UI–0.3 IU/Kg of body weight, in patients aged over 70 years old or with an estimated creatinine clearance below 60 mL/min [44].