DNA methyltransferase 3a (DNMT3A) is involved in chromatin remodeling and has been shown to be important for intestinal tumorigenesis [50], serve as a risk loci in genome-wide association studies (GWAS) studies for Crohn’s disease [51], mediates insulin resistance [52] and has aberrant expression in adipose tissue in mice [53]. The gene discussed is DNMT3A; the disease is Crohn disease.