The cadherin-associated protein beta-1 (CTNNB1) gene (MIM: 116806) which encodes beta-catenin 1 (β-catenin), an integral co-effector of the Wnt/β-catenin pathway and crucial component of the E-cadherens-based adherens junctions, is the most recently associated gene and consequently, its’ phenotypic spectrum an range of variant pathogenicity in relation to vitreoretinal degeneration, is least well understood. Here, CTNNB1 is linked to vitreoretinal degeneration.