CASP1 and lung adenocarcinoma: Conversely, activation of the NLRP3 inflammasome promotes the proliferation and migration of lung adenocarcinoma A549 cells, which is related to the ability of the NLRP3 inflammasome to mediate the release of IL-18 and IL-1β through caspase-1-dependent or caspase-1-independent pathways [11].