We observed that NLRP7 (n = 8), AIM2 (n = 10), CASP8 (n = 6), GSDMA (n = 5), GSDMB (n = 8), and GSDMC (n = 12) mainly showed hypomethylation in most cancers, and PLCG1 (n = 11), NLRP6 (n = 13), ELANE (n = 11), CASP6 (n = 5), NLRC4 (n = 12), and PYCARD (n = 8) showed hypermethylation in most cancers. The gene discussed is CASP6; the disease is cancer.