As shown in Fig. 5, IL-6/JAK/STAT3 signalling, allograft rejection, inflammatory response, IL2/STAT5 signalling, tumour necrosis factor (TNF-A) signalling via nuclear factor kappa B (NF-kB), apoptosis KRAS signalling and the P53 pathway were enriched in tumours with high pyroptosis levels, indicating that pyroptosis was positively associated with these pathways. This evidence concerns the gene TNF and neoplasm.