CASP8 mutations are associated with increased risks of cancer, and low expression of CASP8 is closely associated with poor prognosis in patients with cancer; however, CASP8 expression was significantly upregulated in glioblastoma multiforme (GBM) and pancreatic adenocarcinoma (PAAD) [18]. Here, CASP8 is linked to pancreatic adenocarcinoma.