IL6 and neoplasm: As shown in Fig. 5, IL-6/JAK/STAT3 signalling, allograft rejection, inflammatory response, IL2/STAT5 signalling, tumour necrosis factor (TNF-A) signalling via nuclear factor kappa B (NF-kB), apoptosis KRAS signalling and the P53 pathway were enriched in tumours with high pyroptosis levels, indicating that pyroptosis was positively associated with these pathways.