In addition, the Arginine–glycine–aspartic acid (RGD) and urokinase plasminogen activator (uPA), whose receptor integrin αvβ3 and uPAR are overexpressed on human tumor cells [33, 34], were decorated on the surface of O2-PPSiI to transmit the drug into the tumor. The gene discussed is PLAU; the disease is neoplasm.