Based on the research of tumor-targeting nano-drug delivery system, we constructed iRGD modified multifunctional nanoliposome drug delivery system (DOX-CB@lipo-pDNA-iRGD) by combining the nuclear tropism new boron-containing agent (DOX-CB) with the CD47 blocking immunotherapy, followed by the exploration of the therapeutic effect of boron neutron capture immuno-chemotherapy on glioma in situ. The gene discussed is CD47; the disease is glioma.