CD47 and neoplasm: Herein, we established a multifunctional nanoliposome delivery system, DOX-CB@lipo-pDNA-iRGD, based on the tumor targeted delivery ability of iRGD and the nuclear tropism of DOX, to deliver the CD47 gene-targeted CRISPR-Cas9 gene knock-out plasmid and boron delivery drug to the nucleus of tumor tissue as much as possible (Fig. 1).