Next, we tested the therapeutic effect of CARM1i in mouse xenograft models in vivo, and we found that CARM1i had a beneficial therapeutic effect, as demonstrated by the reduced growth rate and eventual reduction in tumor volume, as well as the decreased tumor weight compared to the untreated group injected with CARM1-overexpressing cells (Fig. 6E–G). Here, CARM1 is linked to neoplasm.