Therefore, it was determined that there would be no underlying disease such as CML, the patient was diagnosed as B-ALL with t(9;22)(q34.1;q11.2) and received induction chemotherapy of modified Hyper-CVAD regimen (cyclophosphamide, vincristine, adriamycin, dexamethasone and pegylated asparaginase) with imatinib. The gene discussed is ASPG; the disease is acute lymphoblastic leukemia.