However, such factors as diabetes (OR = 1.03, 95%CI: 0.88–1.20, P = 0.7415), obesity status (OR = 1.00, 95%CI: 0.92–1.10, P = 0.9254), ECOG PS (OR = 1.39, 95%CI: 0.93–2.07, P = 0.1119), white blood cell count (OR = 1.90, 95%CI: 0.88–4.11, P = 0.1026), CRP (OR = 1.39, 95%CI: 0.77–2.50, P = 0.2735), lymphocyte count (OR = 1.02, 95%CI: 0.76–1.36, P = 0.9093), D-dimer (OR = 1.05, 95%CI: 0.98–1.13, P = 0.1387), and creatine kinase (OR = 1.52, 95%CI: 0.83–2.77, P = 0.1762) did not obviously influence the severe disease of cancer patients with COVID-19 (Additional file 7: Appendix 7). The gene discussed is CRP; the disease is obesity due to melanocortin 4 receptor deficiency.