The disease activity of patients with RA was scored by DAS28-CRP, and the patients were divided into four groups according to DAS28, disease inactivity group (DAS28 < 2.6), low disease activity group (2.6 ≤ DAS28 < 3.2), moderate disease activity group (3.2 ≤ DAS28 < 5.1) and high disease activity group (5.1 ≤ DAS28) respectively. The gene discussed is CRP; the disease is rheumatoid arthritis.