LRP8 and non-small cell lung carcinoma: After transfecting plasmids into NSCLC cells, the plasmids showed a high transfection efficiency, as reflected by a significantly decreased LRP8 expression in the LRP8 siRNA groups in H1299 and H460 cells, and significantly increased LRP8 expression in the LRP8 overexpression group in H1975 cells (Figures 2(a) and (d)).