MTOR and colorectal cancer: Cell and animal experiments indicated that glycyrrhizic acid, quercetin, and homoharringtonine exhibited strong anticancer activity in colon and colorectal cancer progression by inhibiting sirtuin 3, phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT), and PI3K/AKT/mechanistic target of rapamycin kinase (mTOR) signaling pathways [36–38].