The role of FFAR-2 in regulating intestinal inflammatory responses was previously investigated as FFAR-2-deficient mice have exacerbated disease symptoms in induced colitis as verified by reduced colon length, an amplified disease activity index and severe colonic inflammation; these results recommended that FFAR-2 arbitrates the protecting effects of SCFA in intestinal inflammation [39]. This evidence concerns the gene FFAR2 and colitis.