CRYAB and Parkinson disease: CRYAB is a chaperone that act as a potent inhibitor of α-syn amyloid fibril formation, preventing aggregation and its ensuing neurotoxicity.73,74 YWHAQ or the 14-3-3θ protein also has a chaperone function and it reduces α-syn toxicity and propagation.75,76 Thus, we speculate that the decrease in CRYAB and 14-3-3θ are directly related to hα-syn accumulation and that it may be a critical mechanism by which α-syn propagation and toxicity arise in Parkinson’s disease.