In line with this, a group of related human developmental overgrowth syndromes, including the Weaver, Weaver-like, Cohen-Gibson, and Overgrowth and Intellectual Disability syndromes, appear to be caused by heterozygous mutations in EED, EZH2 or SUZ12 (reviewed by Burkardt et al., 2019; Cyrus et al., 2019). This evidence concerns the gene EZH2 and Overgrowth.