Following virus infection Irf3-/-xIrf7-/-DKO mice had similar levels of IFN mRNA induction compared to B6 mice with either JCV or INKV infection, while the Mavs-/-xUnc93b1.3D mice had little to no IFN mRNA upregulation in response to infection (Fig 8B and 8D). This evidence concerns the gene MAVS and infection.