The results showed that in ccRCC, AQP9 promoted tumor-associated macrophage polarization, inhibited the recruitment of natural killer (NK) cells and CD8+ T cells by inhibiting P53 and activating the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway, and ultimately stimulated a reorientation of the tumor microenvironment in ccRCC toward tumor-friendly directions [56]. This evidence concerns the gene AQP9 and nonpapillary renal cell carcinoma.