The results also demonstrated that high expression of AQP1(P = 4.2E-08) and AQP7(P = 5.2E-03) were associated with better prognosis as well as high AQP9(P = 2.1E-03) expression was correlated with a poorer prognosis of the DFS in ccRCC. Here, AQP9 is linked to nonpapillary renal cell carcinoma.