The multivariate Cox regression analysis showed that low mRNA expression of AQP1 (HR = 0.484, 95%CI: 0.308–0.759, and p = 0.002) and long mRNA expression of AQP9 (HR = 1.622, 95%CI: 1.032–2.550, and p = 0.036) were independently associated with significantly shorter OS of ccRCC patients (Tables 5–8). This evidence concerns the gene AQP9 and nonpapillary renal cell carcinoma.