Results revealed that high mRNA expression levels of AQP0(P = 0.013), AQP8(P = 0.024), AQP9(P = 8.3E-04) were significantly related to shorter OS of patients with ccRCC while high mRNA expression levels of AQP1(P = 1.8E-09), AQP4(P = 1.1E-04), AQP7(P = 0.011) were associated with longer OS time (Fig 8). Here, AQP8 is linked to nonpapillary renal cell carcinoma.