IL18 and COVID-19: Takahashi et al. (2020) while monitoring 98 patients with COVID-19 admitted to Yale Hospital from March 18th to May 9th, 2020, noticed significantly higher levels of pro-inflammatory chemokines and cytokines in male participants, such as IL-8, IL-18 and CCL5, and a significantly lower number of T cells, both in the total count and in the proportion of live cells, over the course of the disease, which contributed to the worsening of their clinical condition [22].