COL3A1 and Ehlers-Danlos syndrome, vascular type: As the betablocker celiprolol showed benefits in vEDS patients [10,11], we tested whether this drug could have any effect on aortic rupture in Col3a1+/G182R mice especially because of its specific pharmacodynamic profile adding a β(1)-adrenoceptor antagonist to a β(2)-adrenoceptor agonist action [21].