In AD, oxidative stressincreases Aβ production and tau phosphorylation to generateaberrant protein aggregates.15 In turn,these aggregates induce more ROS, leading to mitochondrial dysfunctionand generating an exacerbated oxidative stress status.16 PD patients show reduced mitochondrial complexI activity that has been related to ROS overproduction and higherneuronal susceptibility.17 This evidence concerns the gene MAPT and Alzheimer disease.