QR2 catalyzes the reduction of 1,2- and 1,4-quinones into unstablesemiquinones, generating ROS.34 It is recognizedas a melatonin binding site, and indeed, melatonin is a QR2 inhibitor,which would explain many of its protective properties against oxidativestress.35 Text mining on Europe PMC revealsthe overexpression of NQO2 in AD patients,36 genetic polymorphisms associated with PD,37 an inhibitory role in memory formation and consolidation,38 and activity of NQO2 inhibitors in neuroprotectiveassays39 (see bibliographic data in Supporting Information 2). The gene discussed is NQO2; the disease is Alzheimer disease.