Moreover, 3xTg-ADmice exhibited significantly reduced levels of hyperphosphorylatedtau and Aβ in hippocampal neurons, which enhanced memory andlearning behaviors.32 Another study, performedin astrocytes differentiated from induced pluripotent stem cells derivedfrom AD patients carrying the presenilin-1 PSEN1ΔE9 mutation,showed that lentiviral activation of the NRF2 pathway reduced amyloidsecretion, normalized cytokine release, and increased glutathione(GSH) secretion.33 Additional Europe PMC-scoredarticles by Open Targets linking NFE2L2 to NDs can be accessed in Supporting Information 2. This evidence concerns the gene NFE2L2 and Alzheimer disease.