NQO2 and amnesia: Furthermore, downregulationof the QR2 function by selective inhibitors has beneficial effects,both in in vitro and in vivo experiments.In cultured rat embryonic hippocampal neurons, the selective QR2 inhibitorsS26695 and S29434 protected against menadione-induced cell death andS26695 also significantly inhibited scopolamine-induced amnesia inlive mice.42 Overall association scoresand evidence counts between NQO2 and NDs in Europe PMC and PhenoDigmdatabases are summarized in Figure S3 (Supporting Information 1).