Unlike the cancer drivers mentioned above, based on the current evidence, F. nucleatum is a “passenger”19 bacteria that colonizes an already formed tumor and accelerates its progression through manipulation of β‐catenin signaling,43, 44 host cytokine production (IL‐8 and CXCL1),134 anti‐tumor immunity, and chemoresistance. The gene discussed is CXCL1; the disease is cancer.