MAPT and Alzheimer disease: Based on genome‐wide association study (GWAS) analysis, AD is described as a multiplex model that is not only challenged by aging, immune response and inflammation, amyloidosis, tau accumulation, and cholesterol, but also newly enriched by possible mechanisms like endocytosis, ubiquitination (ie, the posttranslational modification of adding ubiquitin molecules to lysine residues), and vascular alterations.