High‐density lipoprotein composition also seemed to play a major role in lipopolysaccharide neutralization, since apolipoprotein A1 and the core lipids (ie, triglycerides and cholesteryl esters) were associated with high endotoxemia, whereas the high‐density lipoprotein surface lipids (ie, free cholesterol and phospholipids) were associated with low endotoxemia. Here, APOA1 is linked to serum lipopolysaccharide activity.