The first three principal components associating with endotoxemia included (1) very low‐density lipoproteins parameters, apolipoprotein B, and fatty acids, including monounsaturated fatty acids and saturated fatty acids; (2) a large mean diameter of very low‐density lipoproteins, low high‐density and low‐density lipoprotein cholesterol contents, and small high‐density lipoprotein particle size; and (3) high levels of lipid‐rich high‐density lipoprotein particles, fatty acids, monounsaturated fatty acids, saturated fatty acid, and low ratio of apolipoprotein B/apolipoprotein A1. Here, APOB is linked to serum lipopolysaccharide activity.