DCN and Acute hepatitis: Conversely, acetaminophen suppressed and DCN normalized expression of the anti-inflammatory cytokine IL-10, in accord with studies reporting that IL-10 negatively regulates the production of pro-inflammatory cytokines such as TNF-α and inhibits the expression of NF-κB during acute hepatitis, including acetaminophen hepatotoxicity (Gardner et al. 2002; Gaddi et al. 2012; Dong et al. 2019).