However, immunoregulatory parameters such as CD25, CD25CD71, PPAR, GARP, and FOXP3 positive cells are associated with the occurrence of allergic rhinitis, hypersensitivity to mites, as well as increased eosinophil counts and wheezing in addition to colds in API, suggesting their possible role in the regulation of peripheral tolerance. This evidence concerns the gene PPARA and allergic rhinitis.