We profiled sub-chromosomal changes across 13 chromosome arms commonly altered in MPNST (Figure 2), including 4q (PDGFRA), 5p (TERT), 6q (TBX1), 7p (EGFR), 7q (BRAF), 8q (EXT1), 9p (CDKN2A and CDKN2B), 10q (PTEN), 11p (EXT2), 11q (EED), 15q (IDH2), 17p (TP53), and 17q (NF1 and SUZ12) (Supplementary file 4). Here, IDH2 is linked to malignant peripheral nerve sheath tumor.