We profiled sub-chromosomal changes across 13 chromosome arms commonly altered in MPNST (Figure 2), including 4q (PDGFRA), 5p (TERT), 6q (TBX1), 7p (EGFR), 7q (BRAF), 8q (EXT1), 9p (CDKN2A and CDKN2B), 10q (PTEN), 11p (EXT2), 11q (EED), 15q (IDH2), 17p (TP53), and 17q (NF1 and SUZ12) (Supplementary file 4). This evidence concerns the gene TP53 and malignant peripheral nerve sheath tumor.