MAPT and neurodegenerative disease: Previously, we and others used electron cryo-microscopy (cryo-EM) to determine the atomic structures of the cores of tau filaments extracted from the brains of individuals with a number of neurodegenerative diseases (Fitzpatrick et al., 2017; Falcon et al., 2018a; Falcon et al., 2019; Falcon et al., 2019; Arakhamia et al., 2021; Zhang et al., 2020; Shi et al., 2021).