Thus, a mixture of all six isoforms is present in the tau filaments of Alzheimer’s disease (AD), chronic traumatic encephalopathy (CTE), and other diseases; in Pick’s disease (PiD), filaments are composed of only 3R tau isoforms; and in progressive supranuclear palsy (PSP), corticobasal degeneration (CBD), globular glial tauopathy (GGT), argyrophilic grain disease (AGD), and other tauopathies, filaments are composed of only 4R tau isoforms. This evidence concerns the gene MAPT and Pick disease.