To detect the role of NF-κB activity in the effects of HSCARG in CHD,NF-κB plasmid and siNF-κB plasmid were used to regulate expressionof NF-κB in in vitro model by regulation of HSCARG.NF-κB plasmid induced p-NF-κB and p47phox protein expressions,increased MDA and ROS production levels, and reduced SOD, GSH-PX, and GSH levelsin in vitro model by overexpression of HSCARG (Figure 6). This evidence concerns the gene NMRAL1 and coronary artery disorder.