Expression of iNOS is induced in responseto cytokines and other agents[7].Endothelial nitric oxide synthase (eNOS) is an enzyme that mediates oxidative stressin ischemia/reperfusion injury[8].Also, eNOS is a major isoform that regulates vascular function, and is a powerfulvasodilator[9]. The gene discussed is NOS3; the disease is ischemia reperfusion injury.