As the Km of GLUT1 is 7–26 mM [334,335] while the Km of GLUT3 is less than 2 mM [335], GLUT3 is better able to facilitate glucose uptake at the low glucose concentrations characteristic of the TME, suggesting that tumor-T cell competition for glucose may be relevant in determining cancer prognosis. This evidence concerns the gene SLC2A3 and cancer.