SLC5A2 and Hyperglycemia: Several case reports have suggested that the efficacy of SGLT2 inhibitors and low-carbohydrate diets to prevent PI3K inhibitor-induced hyperglycemia may translate to humans [161,162], and a search of the U.S. ClinicalTrials.gov registry on November 21, 2021 revealed three ongoing trials examining the efficacy of adding SGLT2 inhibitors and/or low-carbohydrate diets in patients treated with PI3K inhibitors.