There exists a wide spectrum of insulin resistance, where an insulin sensitive individual will have low basal and postprandial insulin concentrations, an insulin resistant individual will have hyperinsulinemia in both settings, and an individual with overt type 2 diabetes, whose pancreatic beta cells cannot properly secrete insulin in response to elevated glucose, presents with hyperglycemia without hyperinsulinemia [39]. This evidence concerns the gene INS and hyperinsulinism.