Multiple mechanisms have been suggested to mediate exercise's anti-cancer effects: enhanced angiogenesis and thus increased immune cell infiltration [280,284], forced-swimming-induced catecholamine induction has been suggested to enhance natural killer cell infiltration into tumors [282,287], and exercise training induced improvements in insulin resistance [288,289], and thus reductions in tumor anabolism, among others, have been suggested. Here, INS is linked to neoplasm.