RIPK3 and COVID-19: Increased levels of circulating RIPK3 were found in patients with severe COVID-19 [163] and several reports have identified hallmarks of necroptosis signaling across a spectrum of host cells during SARS-CoV-2 infection, including lung epithelial cells [54], neutrophils [54,60], macrophages [54], platelets [43], adipocytes [58], pancreatic islets [61] and in adrenal glands [43].