Although dysplasminogenemia was first identified in a patient with recurrent thrombosis,[4] there have been several reports suggesting that dysplasminogenemia itself may not be a risk factor for thrombosis.[6,9,10] Furthermore, in the homozygous PLG Ala620Thr mouse model, the risk of thrombotic diseases was not increased despite decreased plasmin activity.[11]. This evidence concerns the gene PLG and thrombotic disease.