TNF and rheumatoid arthritis: The EULAR recommends that a risk estimate be performed for each patient and has suggested specific DMARDs, such as anti-tumor necrosis factor and methotrexate, for those with high CV risk, especially those with seropositivity, increased inflammatory markers, long disease duration (>10 years), and/or extra-articular manifestations.[12] Glucocorticoid therapy has been suggested as an adjunctive therapy for early RA due to its anti-inflammatory effects.