ITSN1 and Sepsis: The explanations might be that sepsis is characterized by systematic inflammation; meanwhile, lnc‐ITSN1‐2 mediated inflammation by NOD2/RIP2/nuclear factor‐κB (NF‐κB) signaling pathway, which could reflect the level of inflammation to some extent21, 26; thus, lnc‐ITSN1‐2 was highly expressed in sepsis patients than it in health controls.