For instance, a study reports that high lnc‐ITSN1‐2 has been found in ankylosing spondylitis patients, meanwhile, it relates to increased IL‐1β cytokine25; another study displays that lnc‐ITSN1‐2 of intestinal mucosa and peripheral blood mononuclear cell in IBD patients is higher than that in health controls18; in critical ill diseases, the high expression of lnc‐ITSN1‐2 has been observed in SAP and AIS patients.16, 22. This evidence concerns the gene IL1B and androgen insensitivity syndrome.